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The Heroic Minds Podcast

Jul 21, 2018

Dr. Collingridge was recruited from Bristol in the U.K. to be the Senior Investigator at Lunenfeld-Tanenbaum Research Institute in Toronto. He is also the chair of the Department of Physiology at the University of Toronto. Dr. Collingridge studies brain mechanisms that control the strength of brain cell connections, and how this fundamental property (known as synaptic plasticity) affects brain function. The work is critical for understanding the cellular basis of learning and memory. Dr. Collingridge aims to find pharmacogenetic methods (drugs) to restore behavioural and cognitive function and to prevent neurodegenerative processes that afflict people with Alzheimer’s and Parkinson’s Disease, and mental illness. From why smells reminds us of our past to research on medication that can reverse the affects of depression to pruning our synapses and the best way to keep our brain young. Enjoy!


Scent Music and Memory (6:00)

10% of our Brain (8:30)

Cant Remember Everything (9:00)

Plasticity (11:20)

Metaplasticity (13:10)

Improving memory (14:30)

Weaken fear response (17:40)

Immune System & Nervous System (26:30)

Nervous system variability (27:00)

Stress on the brain (33:40)

Medication for Alzheimer’s (36:00)

Ketamine and depression (37:30)

Peak plasticity in life (43:20)

Raise pain threshold (44:30)

Inflammation and memory (50:00)

Marijuana vs. Alcohol (56:20)

Keeping your brain young (1:01:20)

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Work Cited:

Park, Pojeong, et al. "NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation." Phil. Trans. R. Soc. B 369.1633 (2014): 20130131.

Nisticò, Robert, et al. "Synaptoimmunology-roles in health and disease." Molecular brain 10.1 (2017): 26.

Bliss, T. V. P., G. L. Collingridge, and R. G. M. Morris. "Synaptic plasticity in health and disease: introduction and overview." (2014): 20130129.

Bortolotto, Zuner A., et al. "An analysis of the stimulus requirements for setting the molecular switch reveals a lower threshold for metaplasticity than synaptic plasticity." Neuropharmacology 55.4 (2008): 454-458.